Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio‐chemo‐mechanical model

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Abstract
A numerical model for the adhesion of osteoblasts on titanium micro‐pillar structures is suggested and a function representing the concentration level of the adhesion on the pillars is constructed based on experimental observation. With the introduction of this function, the bio‐chemo‐mechanical model by Deshpande et al. can predict the formation of actin in osteoblasts when they are laid on arrays of titanium micro‐pillars of various size attached to silicon substrate. A parameter study suggests that each pillar is associated with a different pattern of adhesion. Our finding emphasises a capability of the bio‐chemo‐mechanical model that it can well explain the strong influence of the boundary condition on the formation of actin within the cells.
Funding Information
  • Deutsche Forschungsgemeinschaft (GRK 1505/2)

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