Interaction of estramustine phosphate with microtubule‐associated proteins
Authors:
- Margareta WallinMWMargareta Wallin
- Johanna DeinumJDJohanna Deinum
- Bo FridénBFBo Fridén
- 7 January 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 179 (2) , 289-293
Abstract
We have reported [(1984) Cancer Res., in press] that estramustine phosphate inhibits microtubule assembly and disassembled preformed microtubules. We now present evidence that estramustine phosphate inhibits microtubule assembly by binding to the microtubule‐associated proteins. We have found that: (1) additional microtubule‐associated proteins relieved the inhibition of assembly by estramustine phosphate; (2) 3H‐labelled estramustine phosphate bound predominantly to the microtubule‐associated proteins; and (3) the content of the microtubule‐associated proteins was reduced in taxol reversed estramustine phosphate‐inhibited microtubules.Keywords
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