Palladium-Catalyzed Hydrocyanation of Ynoates: En Route to the Stereodivergent Synthesis of β-Cyanated α,β-Unsaturated Esters via Ligand Controlled Regio- and Stereoselectivity

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Abstract
A Pd-catalyzed highly regio- and stereoselective hydrocyanation was developed, providing a novel approach to the stereodivergent synthesis of β-cyano-substituted acrylates in good yields with a wide substrate scope. The judicious selection of ligands was crucial for elegant control over the stereodivergence. Furthermore, the success of the E-hydrocyanation hinges on the right matching of Pd and L1, which not only ensured the catalytic activity but also prevented the formation of α-cyanation products.
Funding Information
  • Natural Science Foundation of Hunan Province (2023JJ40124)
  • China Postdoctoral Science Foundation (2022M721086)
  • National Natural Science Foundation of China (22278265, 22302063, U22B20137)
  • Natural Science Foundation of Zhejiang Province (LR24B020002)
  • Hangzhou Normal University (4095C50222204165)

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