Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death

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Abstract
Significance: Unfortunately, the need for ideal medical treatment of acute ischemic stroke is still largely unmet. One of the contributing factors to the deleterious neuronal death is the opening of acid-sensing ion channels (ASICs) at reduced pH, which in turn, activates other calcium-permeable channels that initiate the catastrophic cascade. Here, we report the discovery of an antibody that blocks the ASIC1a with high specificity and potency. Infusion of this antibody reduces the damaged area from brain ischemia in the murine stroke model. We hypothesize that using antibodies to target ASIC1a is a valid approach for future stroke therapy. The antibody that we report here has the potential to be further developed as drug candidate.
Funding Information
  • JPB Foundation (465)

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