Hyperemesis Gravidarum in Eastern Asian Population

Authors:
  • NUNorichika Ushioda
    Norichika Ushioda
  • MNMasaaki Nagamatsu
    Masaaki Nagamatsu
  • TKTadashi Kimura
    Tadashi Kimura
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Abstract
Objective: To investigate the clinical features of hyperemesis gravidarum in Eastern Asian women. Method: Retrospective cohort study was conducted based on delivery records. Hyperemesis gravidarum was defined as a pregnancy with severe nausea and vomiting necessitating hospitalization with a body weight loss of over 5% from pre-pregnancy weight with ketonuria. The onset is at 10 weeks of gestation or less. Maternal and neonatal variables were compared. Result: There were 3,350 singleton deliveries in the study period. All subjects were Eastern Asian women. Hyperemesis gravidarum was observed in 119 cases (3.6%). Hyperemesis gravidarum subjects had a smaller pre-pregnancy body weight (50.5 ± 0.64 kg vs. 51.8 ± 0.16 kg, p = 0.046) and a smaller pre-pregnancy body mass index compared to non-hyperemetic subjects (20.2 ± 0.21 kg/m2 vs. 20.8 ± 0.06 kg/m2, p = 0.02). Conclusion: The Eastern Asian population had a significantly higher incidence of hyperemesis gravidarum. Small pre-pregnancy body habitus increased the risk of hyperemesis gravidarum.