B-Mode Enhancement at Phase-Inversion US with Air-based Microbubble Contrast Agent: Initial Experience in Humans
Authors:
- Thomas AlbrechtTAThomas Albrecht
- Christian W. HoffmannCHChristian W. Hoffmann
- Stefan SchettlerSSStefan Schettler
- Aline OverbergAOAline Overberg
- Michael IlgMIMichael Ilg
- Patrick L. von BehrenPBPatrick L. von Behren
- Albrecht BauerABAlbrecht Bauer
- Karl-Jürgen WolfKWKarl-Jürgen Wolf
- 1 July 2000
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 216 (1) , 273-278
Abstract
Pulse- or phase-inversion ultrasonography (US) sums the signals returned from two 180 degrees ultrasound pulses. Linear scattering from tissue results in a signal void while nonlinear signals from microbubbles stand out. The technique was applied with a US contrast agent in 39 human subjects. B-mode enhancement of vessels and organ parenchyma was seen in all cases. Enhancement occurred from flowing and stationary microbubbles. The flow-independent enhancement of normal and abnormal tissue represents a major advance in contrast material-enhanced US with many potential applications especially in tumor imaging.Keywords
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