Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog
Authors:
- 7 October 2014
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 21 (11) , 1013-1015
Abstract
PnuC transporters catalyze cellular uptake of the NAD+ precursor nicotinamide riboside (NR) and belong to a large superfamily that includes the SWEET sugar transporters. We present a crystal structure of Neisseria mucosa PnuC, which adopts a highly symmetrical fold with 3+1+3 membrane topology not previously observed in any protein. The high symmetry of PnuC with a single NR bound in the center suggests a simple alternating-access translocation mechanism.Keywords
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