Expression of marine H–2Kb histocompatibility antigen in cells transformed with cloned H–2 genes
- 1 August 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5874) , 529-534
Abstract
Cosmids containing H–2 histocompatibility antigen genes of the H–2b haplotype have been isolated. One of these genes expresses a 45,000 molecular weight protein, indistinguishable from H–2Kb when introduced into mouse L cells. These H–2Kb transformed L cells can be killed by allospecific anti-H–2Kb cytotoxic T cells. Moreover, when infected with influenza virus, they can be killed by an H–2Kb–restricted, influenza virus–specific cytotoxic T cell line. These results show that expression of the H–2Kb gene product on the L-cell surface is sufficient to make it a target for specific T-cell killing.Keywords
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