Reaction Rates for the Production of Polyphenylalanine and Polyserine by Solid Phase Peptide Synthesis with Low Excesses of the Symmetrical Anhydride
Authors:
- 1 June 1989
- journal article
- research article
- Published by Wiley in Biotechnology Progress
- Vol. 5 (2) , 51-56
Abstract
Continuous monitoring with UV‐absorbance was used to obtain coupling reaction rates between t‐Boc amino symmetrical anhydrides and the amino terminus of the peptide by solid phase synthesis. A kinetic model was established for the synthesis of polyserine and polyphenylalanine with rate constants determined over selected reaction temperatures, mixing rates, peptide chain lengths, and excess mole ratios of t‐Boc amino acid.Keywords
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