Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice
Authors:
- 31 July 2009
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 52 (10) , 2130-2141
Abstract
Pancreatic beta cells undergo dynamic remodelling during the perinatal period, with enhanced neogenesis, proliferation and apoptosis observed. The molecular mechanisms responsible for these processes have yet to be elucidated. Survivin is an inhibitor of apoptosis, first described as being exclusively expressed in tumour and embryonic tissues with regulatory functions in mitosis and apoptosis. The aim of the present study was to define the essential physiological role of survivin in the pancreas.Keywords
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