New progress in research of intestinal microbiota in fatty liver disease
Authors:
- Ying LiYLYing Li
- Jun-Jie HouJHJun-Jie Hou
- Xin WangXWXin Wang
- Shuai SuSSShuai Su
- Yu-Ming WangYWYu-Ming Wang
- Jie ZhangJZJie Zhang
Open Access
- 8 December 2021
- journal article
- Published by Baishideng Publishing Group Inc. in World Chinese Journal of Digestology
- Vol. 29 (23) , 1355-1361
Abstract
目前, 肠道菌群已成为一个当今研究的热点问题之一. 脂肪性肝病是指由于各种原因引起的肝细胞内脂肪堆积过多的病变, 引起肝的正常结构、生理及生化功能受损, 最终出现临床症状的一类疾病总称, 一般包括非酒精性脂肪性肝病和酒精性肝病两大类. 肠道菌群和肠道通透性的变化可以通过肠-肝轴进一步影响脂肪性肝病的发展. 同样, 在脂肪性肝病的发生发展过程中, 肠道菌群的也发生不同程度的改变. 本文主要介绍肠-肝轴与脂肪性肝病的关系、脂肪性肝病进展过程中肠道菌群的变化及益生菌在脂肪性肝病治疗中的应用新进展.This publication has 41 references indexed in Scilit:
- Global burden of NAFLD and NASH: trends, predictions, risk factors and preventionNature Reviews Gastroenterology & Hepatology, 2017
- Gut microbiota dysbiosis in patients with non-alcoholic fatty liver diseaseHepatobiliary & Pancreatic Diseases International, 2017
- Gut-liver axis at the frontier of host-microbial interactionsAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2017
- Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in miceJournal of Hepatology, 2017
- Interaction between gut microbiota and toll-like receptor: from immunity to metabolismJournal of Molecular Medicine, 2016
- CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligandsNature Medicine, 2016
- Intestinal microbiota contributes to individual susceptibility to alcoholic liver diseaseGut, 2015
- Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non‐alcoholic steatohepatitisAlimentary Pharmacology & Therapeutics, 2014
- Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseNature Genetics, 2008
- Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: Role of endotoxinJournal of Hepatology, 2008