Reciprocal Interference Between Specific CJD and Scrapie Agents in Neural Cell Cultures
Authors:
- 21 October 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5747) , 493-496
Abstract
Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with superinfection by a more virulent human-derived CJD agent (FU-CJD) and does not require pathological prion protein (PrPres). Using a rapid coculture system, we found that a neural cell line free of immune system cells similarly supported substantial CJD agent interference without PrPres. In addition, SY-CJD prevented superinfection by sheep-derived Chandler (Ch) and 22L scrapie agents. However, only 22L and not Ch prevented FU-CJD infection, even though both scrapie strains provoked abundant PrPres. This relationship between particular strains of sheep- and human-derived agents is likely to affect their prevalence and epidemic spread.Keywords
This publication has 19 references indexed in Scilit:
- New molecular markers of early and progressive CJD brain infectionJournal of Cellular Biochemistry, 2004
- Viral and host genetic factors regulating HIV/CNS diseaseJournal of NeuroVirology, 2004
- Unique inflammatory RNA profiles of microglia in Creutzfeldt–Jakob diseaseProceedings of the National Academy of Sciences, 2003
- Gene silencing as an adaptive defence against virusesNature, 2001
- Attenuated Creutzfeldt–Jakob Disease agents can hide more virulent infectionsNeuroscience Letters, 2000
- Successful Transmission of Three Mouse-Adapted Scrapie Strains to Murine Neuroblastoma Cell Lines Overexpressing Wild-Type Mouse Prion ProteinJournal of Virology, 2000
- Transmission of the BSE Agent to Mice in the Absence of Detectable Abnormal Prion ProteinScience, 1997
- Viral particles are required for infection in neurodegenerative Creutzfeldt-Jakob disease.Proceedings of the National Academy of Sciences, 1995
- Amphotericin B treatment dissociates in vivo replication of the scrapie agent from PrP accumulationNature, 1992
- Defective Interfering Viruses and Infections of Animals1986