Mesoscale-duration activated states gate spiking in response to fast rises in membrane voltage in the awake brain
- 1 August 2017
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 118 (2) , 1270-1291
Abstract
We analyzed subthreshold activity preceding spikes in hippocampus and barrel cortex of awake mice. Aperiodic voltage ramps extending over tens to hundreds of milliseconds consistently precede and facilitate spikes, in a manner dependent on both their amplitude and their duration. These voltage ramps represent a “mesoscale” activated state that gates spike production in vivo.Keywords
Funding Information
- MIT Intelligence Initiative
- Friends of the McGovern Institute Fellowship
- NIH Director's Pioneer Award (1DP1NS087724)
- NIH Transformative Award (1R01MH103910-01)
- NIH (1R01 NS067199, 1R01 NS067199, 1R01EY023173, 1R01DA029639)
- New York Stem Cell Foundation (NYSCF)
- NSF (DMS 1042134)
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