Limited Additional Value of a Chest CT in Whole-Body Staging with PET-MRI: A Retrospective Cohort Study

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Abstract
Hybrid PET-MRI systems are being used more frequently. One of the drawbacks of PET-MRI imaging is its inferiority in detecting lung nodules, so it is often combined with a computed tomography (CT) of the chest. However, chest CT often detects additional, indeterminate lung nodules. The objective of this study was to assess the sensitivity of detecting metastatic versus indeterminate nodules with PET-MRI compared to chest CT. A total of 328 patients were included. All patients had a PET/MRI whole-body scan for (re)staging of cancer combined with an unenhanced chest CT performed at our center between 2014 and 2020. Patients had at least a two-year follow-up. Six percent of the patients had lung metastases at initial staging. The sensitivity and specificity of PET-MRI for detecting lung metastases were 85% and 100%, respectively. The incidence of indeterminate lung nodules on chest CT was 30%. The sensitivity of PET-MRI to detect indeterminate lung nodules was poor (23.0%). The average size of the indeterminate lung nodules detected on PET-MRI was 7 ± 4 mm, and the missed indeterminate nodules on PET-MRI were 4 ± 1 mm (p < 0.001). The detection of metastatic lung nodules is fairly good with PET-MRI, whereas the sensitivity of PET-MRI for detecting indeterminate lung nodules is size-dependent. This may be an advantage, limiting unnecessary follow-up of small, indeterminate lung nodules while adequately detecting metastases.
Funding Information
  • Research Training Group 2375 “Tumor-targeted Drug Delivery” (331065168, 445703531, 321137804, 70113779, 70113780, 16GW0319K)
  • Clinical Research Unit CRU 5011 “Integrating emerging methods to advance translational kidney research (InteraKD)” (331065168, 445703531, 321137804, 70113779, 70113780, 16GW0319K)
  • Research Unit 2591 “Severity assessment in animal-based research” (331065168, 445703531, 321137804, 70113779, 70113780, 16GW0319K)
  • German Cancer Aid (331065168, 445703531, 321137804, 70113779, 70113780, 16GW0319K)
  • German Federal Ministry of Research and Education (331065168, 445703531, 321137804, 70113779, 70113780, 16GW0319K)

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