Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry Fragaria vesca var. nubicola Lindl. ex Hook.f.
Open Access
- 25 July 2017
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Pharmacology
- Vol. 8, 469
Abstract
Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, Fragaria vesca var. nubicola Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol (1) and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol (2) based on spectroscopic data through IR, UV, 1H-NMR, 13C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds 1 and 2 were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.Keywords
This publication has 24 references indexed in Scilit:
- Clarifying the Identity of the Main Ellagitannin in the Fruit of the Strawberry, Fragaria vesca and Fragaria ananassa Duch.Journal of Agricultural and Food Chemistry, 2012
- Effect of fruit extract of Fragaria vesca L. on experimentally induced inflammatory bowel disease in albino ratsIndian Journal of Pharmacology, 2011
- A comparative study of analgesic property of whole plant and fruit extracts of Fragaria vesca in experimental animal modelsBangladesh Journal of Pharmacology, 2008
- Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension testsEuropean Neuropsychopharmacology, 2007
- Free radical scavenging activity and phenolic content in achenes and thalamus from Fragaria chiloensis ssp. chiloensis, F. vesca and F. x ananassa cv. ChandlerFood Chemistry, 2007
- Identification of phenolic compounds in strawberries by liquid chromatography electrospray ionization mass spectroscopyFood Chemistry, 2006
- The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in miceNeuroscience & Biobehavioral Reviews, 2005
- Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disordersLife Sciences, 2004
- Potential Impact of Strawberries on Human Health: A Review of the ScienceCritical Reviews in Food Science and Nutrition, 2004
- Antitumor effect of agrimoniin, a tannin of Agrimonia pilosa ledeb., on transplantable rodent tumors.The Japanese Journal of Pharmacology, 1987