Addition of organolithium reagents to α-(trifluoromethyl)styrene: concise synthesis of functionalised gem-difluoroalkenes
Authors:
- Jean-Pierre BéguéJBJean-Pierre Bégué
- Danièle Bonnet-DelponDBDanièle Bonnet-Delpon
- Michael H. RockMRMichael H. Rock
- 1 January 1996
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 12,p. 1409-1413
Abstract
The treatment of α-(trifluoromethyl)styrene with organolithium reagents results in the selective formation of gem-difluoroalkenes in good-to-excellent yields. This reaction has been applied to the synthesis of 3-gem-difluoro-2-phenylallylic amines and other functionalised gem-difluoroalkenes.Keywords
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