Design, synthesis, crystal structures and anticancer activity of 4-substituted quinolines to target PDK1

This publication has 28 references indexed in Scilit:

• Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors
  Journal of Medicinal Chemistry, 2011
• Discovery of PDK1 Kinase Inhibitors with a Novel Mechanism of Action by Ultrahigh Throughput Screening
  Journal of Biological Chemistry, 2010
• Prediction of Absolute Solvation Free Energies using Molecular Dynamics Free Energy Perturbation and the OPLS Force Field
  Journal of Chemical Theory and Computation, 2010
• The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)
  European Journal of Medicinal Chemistry, 2010
• Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells
  Experimental Cell Research, 2008
• Discovery of Dibenzo[c,f][2,7]naphthyridines as Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 Inhibitors
  Journal of Medicinal Chemistry, 2007
• Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice
  Carcinogenesis, 2007
• Mercury: visualization and analysis of crystal structures
  Journal of Applied Crystallography, 2006
• FDA Drug Approval Summary: Pemetrexed for Injection (Alimta®) for the Treatment of Non-Small Cell Lung Cancer
  The Oncologist, 2005
• Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
  Advanced Drug Delivery Reviews, 1997