The Role of the Cytoskeleton in Neuromuscular Junction Formation
- 1 January 2006
- journal article
- Published by Springer Nature in Journal of Molecular Neuroscience
- Vol. 30 (1-2) , 115-118
Abstract
The cytoskeleton plays a vital role in neuromuscular junction (NMJ) formation. It is responsible for shaping synaptic membrane into folds opposed to presynaptic active zones and anchoring acetylcholine receptors (AChRs) to the crest of the junctional folds. Acetylcholine receptors (AChRs) associate with the actin cytoskeleton, the disruption of which affects spontaneous and agrin-induced AChR clusters (Prives et al., 1982; Connolly, 1984; Peng and Phelan, 1984; Bloch, 1986; Dai et al., 2000). How AChRs are tethered to the actin cytoskeleton remains unclear.Keywords
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