Cardiovascular changes in dogs given diazepam and diazepam-ketamine

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Abstract
SUMMARY: The cardiopulmonary consequences of diazepam (0.5 mg/kg, iv) followed by ketamine (10 mg/kg, iv) were evaluated in 11 dogs. Diazepam did not exhibit a tranquilizing effect and was frequently associated with excessive excitement. It produced minimal cardiopulmonary effects, except for a significant increase in heart rate. Ketamine administration was associated with less cardiovascular stimulation when administered after diazepam than it did when administered alone; the respiratory depression was greater. Compared with ketamine alone, the diazepam-ketamine combination was associated with more vomition, less muscle hypertonus, less seizure activity, and less salivation.

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