Caenorhabditis elegans phosphatase complexes in UniProtKB and Complex Portal

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Phosphatases play an essential role in the regulation of protein phosphorylation. Less abundant than kinases, many phosphatases are components of one or more macromolecular complexes with different substrate specificities and specific functionalities. The expert scientific curation of phosphatase complexes for the UniProt and Complex Portal databases supports the whole scientific community by collating and organising small‐ and large‐scale experimental data from the scientific literature into context‐specific central resources, where the data can be freely accessed and used to further academic and translational research. In this review, we discuss how the diverse biological functions of phosphatase complexes are presented in UniProt and the Complex Portal, and how understanding the biological significance of phosphatase complexes in Caenorhabditis elegans offers insight into the mechanisms of substrate diversity in a variety of cellular and molecular processes.
Funding Information
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • National Heart, Lung, and Blood Institute
  • National Institute of General Medical Sciences
  • Staatssekretariat für Bildung, Forschung und Innovation
  • National Institute of Allergy and Infectious Diseases
  • National Human Genome Research Institute
  • National Eye Institute
  • European Molecular Biology Laboratory
  • National Institute of Mental Health (U24HG007822)

This publication has 70 references indexed in Scilit: