The role of copper transporter ATP7A in platinum-resistance of esophageal squamous cell cancer (ESCC)
Authors:
Open Access
- 1 January 2016
- journal article
- Published by Ivyspring International Publisher in Journal of Cancer
- Vol. 7 (14) , 2085-2092
Abstract
Purpose: Platinum derivatives, such as cisplatin (DDP), carboplatin and oxaliplatin, are widely used components of modern cancer chemotherapy including esophageal squamous cell cancer (ESCC). However, their roles are limited by the impact of intrinsic/acquired resistance mechanisms on tumor responses. Recent studies have shown that the mammalian copper transporters CTR1, ATP7A and ATP7B are involved in cisplatin-resistance to some cancers.Keywords
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