Characterizing cell interactions at scale with made-to-order droplet ensembles (MODEs)
Open Access
- 24 January 2022
- journal article
- research article
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 119 (5)
Abstract
Significance: The study of specific cell–cell interactions at scale would be a significant advancement in single-cell biology with clear utility in immuno-oncology. Our development of Droplet Assembly provides a tool for such studies by extending the benefits of single-cell droplet microfluidics to high-order cell analyses. This technology allows for the construction, sorting, and downstream processing of cell–cell interactions and is compatible with single-cell genomic readouts.Keywords
Funding Information
- Defense Sciences Office, DARPA (D17PC00405)
- HHS | National Institutes of Health (1R43HG010592, 1R43HG010128)
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