Shear tango: dance of the ADAMTS13/VWF complex
Authors:
- 1 September 2008
- journal article
- editorial
- Published by American Society of Hematology in Blood
- Vol. 112 (5) , 1548-1549
Abstract
ADAMTS13, the metalloprotease that regulates the size of von Willebrand factor (VWF),1 is critical in preventing microvascular platelet clumping, such as occurs in thrombotic thrombocytopenic purpura. The article in this issue of Blood by Gao et al addresses how these two proteins use multiple binding sites to facilitate proteolytic regulation of VWF.Keywords
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