Single-cell transcriptomics predict novel potential regulators of acute epithelial restitution in the ischemia-injured intestine
- 1 March 2025
- journal article
- Published by American Physiological Society in American Journal of Physiology-Gastrointestinal and Liver Physiology
- Vol. 328 (3) , G182-G196
Abstract
These studies validate an approach to identify and predict upstream regulation of restituting epithelium in a unique pig intestinal ischemic injury model. Identification of potential molecular mediators of restitution, such as CSF-1, will inform the development of targeted therapeutic interventions for the medical management of patients with ischemia-mediated intestinal injury.Keywords
All Related Versions
Funding Information
- HHS | National Institutes of Health (U01TR002953)
- HHS | National Institutes of Health (T32OD011130)
- HHS | National Institutes of Health (K01OD028207)
- HHS | National Institutes of Health (R01HD095876)
- U.S. Department of Agriculture (NIFA 2019-67017-29372)
- HHS | National Institutes of Health (P30DK034987)
- NCSU | College of Veterinary Medicine, North Carolina State University (EFIG2202-01)
This publication has 46 references indexed in Scilit:
- Histidine and arginine modulate intestinal cell restitution via transforming growth factor-β1European Journal of Pharmacology, 2019
- Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation MappingCell, 2019
- Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound HealingCell Reports, 2018
- Self-renewing Monolayer of Primary Colonic or Rectal Epithelial CellsCellular and Molecular Gastroenterology and Hepatology, 2017
- Large Animal Models: The Key to Translational Discovery in Digestive Disease ResearchCellular and Molecular Gastroenterology and Hepatology, 2016
- Galectin-2 and -4, but not Galectin-1, promote intestinal epithelial wound healing in vitro through a TGF-beta-independent mechanismInflammatory Bowel Diseases, 2008
- Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swineHistochemistry and Cell Biology, 2005
- Healing the epithelium: Solving the problem from two sidesJournal of Gastroenterology, 1997
- Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor βGastroenterology, 1993
- Prostanoids inhibit intestinal NaCl absorption in experimental porcine cryptosporidiosisGastroenterology, 1993