High Levels of Dopamine Activity in the Basal Ganglia of Cigarette Smokers
Authors:
- Raimo K.R. SalokangasRSRaimo K.R. Salokangas
- Harry VilkmanHVHarry Vilkman
- Tuula IlonenTITuula Ilonen
- Tero TaiminenTTTero Taiminen
- J�N BergmanJBJ�N Bergman
- Merja HaaparantaMHMerja Haaparanta
- Olof SolinOSOlof Solin
- Anu AlanenAAAnu Alanen
- Erkka Syvã«¡HtiESErkka Syvã«¡Hti
- Jarmo HietalaJHJarmo Hietala
- 1 April 2000
- journal article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 157 (4) , 632-634
Abstract
The authors' goal was to study presynaptic dopamine activity in smoking and nonsmoking human subjects in vivo. [(18)F]Fluorodopa ([(18)F]DOPA) uptake K(i) values in the basal ganglia of nine smoking and 10 nonsmoking healthy men were measured with positron emission tomography. Significantly higher [(18)F]DOPA uptake was observed in both the putamen (average 17.3% higher) and the caudate (average 30.4% higher) of smokers than in those of nonsmokers. Smoking is related to greater dopamine activity in the human basal ganglia. Nicotine-induced dopamine activity may be a relevant mechanism in dependence on cigarette smoking.Keywords
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