Decision making and decision support for hereditary breast-ovarian cancer susceptibility.
Authors:
- Marc D. SchwartzMSMarc D. Schwartz
- Beth N. PeshkinBPBeth N. Peshkin
- Kenneth P. TercyakKTKenneth P. Tercyak
- Kathryn L. TaylorKTKathryn L. Taylor
- Heiddis ValdimarsdottirHVHeiddis Valdimarsdottir
- 1 January 2005
- journal article
- review article
- Published by American Psychological Association (APA) in Health Psychology
- Vol. 24 (4, Suppl) , S78-S84
Abstract
Genetic testing for disease susceptibility has the potential to revolutionize health care by allowing for individually tailored disease prevention strategies. To achieve this promise, patients and physicians must use the information obtained through genetic testing to make medical decisions that are consistent with patient preferences and that lead to reduced disease morbidity and mortality. However, decisions associated with genetic testing can be complex. In this article, the authors review decision making associated with genetic testing and the medical management of hereditary breast-ovarian cancer susceptibility. They focus on decisions regarding BRCA1/2 testing and prophylactic surgery among BRCA1 and BRCA2 mutation carriers. They highlight the role of patient preferences and decision support in this population. The studies reviewed indicate that although patients' preferences do predict genetic testing and management decisions, other factors also influence their decision making. In particular, the authors discuss the role of anxiety and worry in relation to testing and surgery decisions.Keywords
This publication has 46 references indexed in Scilit:
- Making better decisions: From measuring to constructing preferences.Health Psychology, 2005
- Randomized Trial of a Shared Decision-Making Intervention Consisting of Trade-Offs and Individualized Treatment Information for BRCA1/2 Mutation CarriersJournal of Clinical Oncology, 2004
- Risk as Analysis and Risk as Feelings: Some Thoughts about Affect, Reason, Risk, and RationalityRisk Analysis, 2004
- Bilateral Prophylactic Mastectomy Reduces Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers: The PROSE Study GroupJournal of Clinical Oncology, 2004
- Contribution of Mendelian disorders to common chronic disease: Opportunities for recognition, intervention, and preventionAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, 2004
- Bilateral Prophylactic Oophorectomy and Ovarian Cancer Screening Following BRCA1/BRCA2 Mutation TestingJournal of Clinical Oncology, 2003
- Average Risks of Breast and Ovarian Cancer Associated with BRCA1 or BRCA2 Mutations Detected in Case Series Unselected for Family History: A Combined Analysis of 22 StudiesThe American Journal of Human Genetics, 2003
- Prophylactic Mastectomy or Screening in Women Suspected to Have the BRCA1/2 MutationMedical Decision Making, 2000
- Out of Control: Visceral Influences on BehaviorOrganizational Behavior and Human Decision Processes, 1996
- Anxiety: Towards a decision‐theoretic perspectiveBritish Journal of Mathematical and Statistical Psychology, 1990