Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains
Open Access
- 4 May 2023
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 14 (21) , 5743-5755
Abstract
We have determined the heterogeneous structural ensemble of the tandem SH2 domains of the protein tyrosine phosphatase SHP2 in agreement with experimental data from small-angle X-ray scattering and NMR residual dipolar couplings in solution.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (HU 1971-3/1)
- Deutsche Forschungsgemeinschaft (INST 256/539-1)
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