A double‐blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

Authors:
  • JMJJ McNeil
    JJ McNeil
  • WLWj Louis
    Wj Louis
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Abstract
1 This study was designed to compare in a double‐blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/‐ 13 mg daily; labetalol 308 +/‐ 34 mg daily; metoprolol 234 +/‐ 22 mg daily; and pindolol 24 +/‐2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side‐effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.

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