Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus
Authors:
- Philip ChambersPCPhilip Chambers
- Neil S. MillarNMNeil S. Millar
- Simon G. PlattSPSimon G. Platt
- Peter T. EmmersonPEPeter T. Emmerson
Open Access
- 1 January 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (22) , 9051-9061
Abstract
The nucleotide sequence of the gene encoding the matrix (M) protein of the Beaudette C strain of Newcastle disease virus (NDV) has been determined from overlapping cDNA clones. Control sequences typical of paramyxovirus mRNA start and polyadenylation signals have been identified. Assuming that the M gene starts and finishes at these sequences, the M gene is 1241 nucleotides long and encodes one long open reading frame of 364 amino acids, corresponding to a polypeptide of molecular weight 39605, in good agreement with estimates from SDS gels. The M protein has an amino acid sequence that is both hydrophobic and highly basic. The NDV M protein ha3 sequence homologies to the M proteins of Sendai, measles, canine distemper and respiratory syncytial viruses.Keywords
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