Carrageenan oedema in copper-deficient rats

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Abstract
Carrageenan-induced hind paw oedema has been studied in rats deprived of copper for different lengths of time. A common feature observed in normally fed and copper-deficient rats was the rise of serum copper levels coccurring between 10 and 24 h after the injection of the irritant. After 1 month of copper-deficient diet no differences are seen in the oedema developed by controls and copperdeprived animals, while after 3 months the oedema developed by copper-deficient rats was significantly greater compared with the controls. These results are briefly discussed.
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