Antitumor principles ofStellera chamaejasme L.
Authors:
- 1 June 1997
- journal article
- basic investigations
- Published by Chinese Journal of Cancer Research in Chinese Journal of Cancer Research
- Vol. 9 (2) , 89-95
Abstract
Methanol extract ofStellera chamaejasme L was assessed for antitumor activity by an antitumor active bioassay against murine leukemia P388in vivo. The bioassay-directcd separation of the extract furnished seven diterpene compounds (stellerarin, stelleramacrin, gnidimacrin, pimelea factor P2, subtoxin, huratoxin, simplexin ) and two biflavanone compounds (neochemae-jasmin A and B). Among them, gnidimacrin, stellerarin and stelleramacrin (a novel compound) were found to have high antitumor and cytotoxic activities against P388, L1210 and K562in vivo andin vitro. The results suggested that the diterpene compounds were the potent antitumor principlesof Stellera chamaejasme L.Keywords
This publication has 6 references indexed in Scilit:
- The antitumor activities of gnidimacrin isolated from stellera chamaejasme L.Chinese Journal of Cancer Research, 1996
- Antitumor activity of daphnane-type diterpene gnidimacrin isolated fromStellera chamaejasme LInternational Journal of Cancer, 1996
- Oligo‐ and macrocyclic diterpenes in thymelaeaceae and euphorbiaceae occurring and utilized in yunnan (Southwest China) 4. Tigliane type diterpene esters (phorbol–12,13‐diesters) from Wikstroemia canescensPhytotherapy Research, 1993
- ISOLATION AND STRUCTURES OF TWO NEW C-3/C-3″-BIFLAVANONES, NEOCHAMAEJASMIN A AND NEOCHAMAEJASMIN BChemistry Letters, 1984
- Piscicidal constituents of Stellera chamaejasme L.Chemical and Pharmaceutical Bulletin, 1982
- Gnidimacrin and gnidimacrin 20-palmitate, novel macrocyclic antileukemic diterpenoid esters from Gnidia subcordataJournal of the American Chemical Society, 1976