The Expression Status and Prognostic Value of Cancer Stem Cell Biomarker CD133 in Cutaneous Squamous Cell Carcinoma

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Abstract
Cutaneous squamous cell carcinoma (cSCC) is the second most common form of nonmelanoma skin cancer after basal cell carcinoma1,2 and accounts for 20% of cutaneous malignant neoplasms and most nonmelanoma skin cancer deaths.3-5 An estimated 700 000 new cases of cSCC are diagnosed annually in the United States.6 Similar incidence trends have been noted in China, and because of the growing elderly Chinese population in recent decades,7 cSCC will be an emerging health burden.8

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