Arf5-mediated regulation of mTORC1 at the plasma membrane
Authors:
- 1 April 2023
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 34 (4) , ar23
Abstract
Arf5 is identified as a novel interaction partner with the mTORC1 subunit, Raptor, and a regulator of mTORC1 signaling at PM ruffles. The findings reveal a Arf5-dependent pathway for recruitment and activation of mTORC1 at PM ruffles, a process relevant for spatial and temporal regulation of mTORC1 by receptor and nutrient stimuli.Keywords
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