Objective: The objective of this study was to investigate the relationship between intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) and dynamic contrast-enhanced MRI (DCE-MRI) parameters in soft tissue tumors (STTs). Methods: This retrospective study included patients with histopathologically confirmed STTs who underwent both DCE-MRI and IVIM-DWI between March 2022 and February 2024. Patients with prior therapy and lipomatous tumors were excluded. DCE-MRI parameters (K_trans, K_ep, V_e, iAUC) were obtained from pharmacokinetic maps using manually placed regions of interest (ROIs) in the most perfused tumor areas, avoiding necrotic and cystic regions. Corresponding ROIs were applied to IVIM-DWI maps. IVIM parameters (D, D*, f) were calculated using 11 b-values. Results: Twenty-nine patients (mean age, 56 ± 18 years; 14 malignant, 15 benign) were included. Interobserver agreement was excellent for DCE-MRI parameters, whereas IVIM-DWI parameters showed moderate-to-good agreement, with D showing the lowest reproducibility. In malignant tumors, f demonstrated strong positive correlations with K_trans (r = 0.81, p < 0.001) and iAUC (r = 0.79, p < 0.001), both of which remained significant after correction for multiple comparisons. fD* was higher in malignant than in benign lesions in the unadjusted group comparison; however, diagnostic performance was not evaluated in the present study. No significant differences were observed for DCE-MRI parameters between benign and malignant tumors. Conclusions: IVIM-DWI parameters demonstrated associations with DCE-MRI metrics in malignant STTs and may provide complementary information regarding tumor perfusion. However, the findings should be interpreted cautiously because ROI analysis was limited to a single representative slice. Further validation using larger cohorts and volumetric tumor assessment is required.

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