Holger Petri
Research Subjects
Holger Petri has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- André Reis
Institute of Human Genetics, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
1 shared publication - Bernhard Zabel
Universitätsklinikum Freiburg, Zentrum für Kinder- und Jugendmedizin
1 shared publication - Bernt Popp
Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center of Functional Genomics, Berlin, Germany
1 shared publication - Dagmar Wieczorek
Institut für Humangenetik, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany
1 shared publication - Eva-Christina Prott
Institut für Humangenetik, University of Duisburg-Essen, University Hospital Essen, Essen, Germany
1 shared publication - Inga Freunscht
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Duisburg-Essen, Essen 45147, Germany
1 shared publication
Latest Publications
- Open Access
- 1 January 2013
- Published by Springer Nature in Behavioral and Brain Functions
- Vol. 9 (1) , 20
Behavioral phenotype in five individuals with de novo mutations within the GRIN2B gene
Intellectual disability (ID) is often associated with behavioral problems or disorders. Mutations in the GRIN2B gene (MRD6, MIM613970) have been identified as a common cause of ID (prevalence of 0.5 – 1% in individuals with ID) associated with EEG and behavioral problems. We assessed five GRIN2B mutation carriers aged between 3 and 14 years clinically and via standardized questionnaires to delineate a detailed behavioral phenotype. Parents and teachers rated problem behavior of their affected children by completing the Developmental Behavior Checklist (DBC) and the Conners’ Rating Scales Revised (CRS-R:L). All individuals had mild to severe ID and needed guidance in daily routine. They showed characteristic behavior problems with prominent hyperactivity, impulsivity, distractibility and a short attention span. Stereotypies, sleeping problems and a friendly but boundless social behavior were commonly reported. Our observations provide an initial delineation of the behavioral phenotype of GRIN2B mutation carriers.
- 1 January 2013
- Published by Springer Nature in Behavioral and Brain Functions
- Vol. 9 (1) , 20
Open AccessBehavioral phenotype in five individuals with de novo mutations within the GRIN2B gene
Intellectual disability (ID) is often associated with behavioral problems or disorders. Mutations in the GRIN2B gene (MRD6, MIM613970) have been identified as a common cause of ID (prevalence of 0.5 – 1% in individuals with ID) associated with EEG and behavioral problems. We assessed five GRIN2B mutation carriers aged between 3 and 14 years clinically and via standardized questionnaires to delineate a detailed behavioral phenotype. Parents and teachers rated problem behavior of their affected children by completing the Developmental Behavior Checklist (DBC) and the Conners’ Rating Scales Revised (CRS-R:L). All individuals had mild to severe ID and needed guidance in daily routine. They showed characteristic behavior problems with prominent hyperactivity, impulsivity, distractibility and a short attention span. Stereotypies, sleeping problems and a friendly but boundless social behavior were commonly reported. Our observations provide an initial delineation of the behavioral phenotype of GRIN2B mutation carriers.