Juandell Parker
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Interests
Juandell Parker has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Christina Eaton
Department of Physiology, University of Texas Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
1 shared publication - Irene Iscla
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA
1 shared publication - Paul Blount
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA
1 shared publication - Robin Wray
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390, USA
1 shared publication - Zoltan Kovacs
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, United States
1 shared publication
Latest Publications
- Open Access
- 19 March 2013
- Published by MDPI AG in Biosensors
- Vol. 3 (1) , 171-184
Improving the Design of a MscL-Based Triggered Nanovalve
The mechanosensitive channel of large conductance, MscL, has been proposed as a triggered nanovalve to be used in drug release and other nanodevices. It is a small homopentameric bacterial protein that has the largest gated pore known: greater than 30 Å. Large molecules, even small proteins can be released through MscL. Although MscL normally gates in response to membrane tension, early studies found that hydrophilic or charged residue substitutions near the constriction of the channel leads to pore opening. Researchers have successfully changed the modality of MscL to open to stimuli such as light by chemically modifying a single residue, G22, within the MscL pore. Here, by utilizing in vivo, liposome efflux, and patch clamp assays we compared modification of G22 with that of another neighboring residue, G26, and demonstrate that modifying G26 may be a better choice for triggered nanovalves used for triggered vesicular release of compounds.
- 19 March 2013
- Published by MDPI AG in Biosensors
- Vol. 3 (1) , 171-184
Open AccessImproving the Design of a MscL-Based Triggered Nanovalve
The mechanosensitive channel of large conductance, MscL, has been proposed as a triggered nanovalve to be used in drug release and other nanodevices. It is a small homopentameric bacterial protein that has the largest gated pore known: greater than 30 Å. Large molecules, even small proteins can be released through MscL. Although MscL normally gates in response to membrane tension, early studies found that hydrophilic or charged residue substitutions near the constriction of the channel leads to pore opening. Researchers have successfully changed the modality of MscL to open to stimuli such as light by chemically modifying a single residue, G22, within the MscL pore. Here, by utilizing in vivo, liposome efflux, and patch clamp assays we compared modification of G22 with that of another neighboring residue, G26, and demonstrate that modifying G26 may be a better choice for triggered nanovalves used for triggered vesicular release of compounds.