Janice A. Husted
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Janice A. Husted has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
Anne S. Bassett
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
3 shared publicationsEva W.C. Chow
Clinical Genetics Research Program, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
3 shared publicationsLinda M. Brzustowicz
Department of Genetics, Rutgers University, Piscataway, NJ, United States
2 shared publicationsRashid Ahmed
Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada
2 shared publications- Celia Margaret T. Greenwood
Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada
1 shared publication Sooyeol Lim
Program in Genetics and Genomic Biology, Hospital for Sick Children, Research Institute, Toronto, Ontario, Canada
1 shared publication
Latest Publications
- 31 May 2012
- Published by Elsevier in Schizophrenia Research
- Vol. 137 (1-3) , 166-168
Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition
- 31 May 2012
- Published by Elsevier in Schizophrenia Research
- Vol. 137 (1-3) , 166-168
Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition
- 1 August 2010
- Published by Elsevier in Schizophrenia Research
- Vol. 121 (1-3) , 187-192
Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene
- 1 August 2010
- Published by Elsevier in Schizophrenia Research
- Vol. 121 (1-3) , 187-192
Childhood trauma and genetic factors in familial schizophrenia associated with the NOS1AP gene
- 20 August 2009
- Published by Wiley in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Vol. 150B (6) , 845-853
Heritability of neurocognitive traits in familial schizophrenia
Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P < 0.0001) for all heritable variables. Bivariate analyses suggested that memory‐IQ and visuomotor‐processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition.
- 20 August 2009
- Published by Wiley in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Vol. 150B (6) , 845-853
Heritability of neurocognitive traits in familial schizophrenia
Neurocognitive deficits are considered promising endophenotypes for gene discovery in schizophrenia. Understanding the heritability and genetic inter‐relationships of neurocognitive traits could support their use as alternatives to diagnosis. Participants were 85 adults from 17 multiplex Canadian families with familial schizophrenia linked to 1q23 who had neurocognitive testing results available. Heritability of 13 standard measures assessing motor skills, processing speed, verbal, and visuospatial memory, attention/working memory, executive functioning, and IQ was estimated using variance component models and SOLAR software. We then investigated bivariate relationships between those variables found to be heritable. IQ showed the highest heritability (h2 = 0.64–0.74) and seven other neurocognitive measures, reflecting immediate and delayed verbal memory, attention/working memory, delayed visual memory, processing speed and motor skills, showed significant heritability (h2 = 0.31–0.62) under one or more of the models assessed. A schizophrenia diagnostic covariate was significant (P < 0.0001) for all heritable variables. Bivariate analyses suggested that memory‐IQ and visuomotor‐processing speed formed two groups of heritable traits. The results provide further evidence of the heritability of selected neurocognitive measures, and their relationship to schizophrenia and underlying genetic architecture. Composite measures of memory or processing speed may be heritable phenotypes useful for studies of neurocognition.