CMCarla Meeuwis

Carla Meeuwis

*This is an algorithmically generated author record based on publicly available information.

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Previous Organizations / Institutes

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Carla Meeuwis has a total of 12 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • MRI-guided breast biopsy at 3T using a dedicated large core biopsy set: Feasibility and initial results

    by Carla Meeuwis, Ritse M. Mann, Roel. D.M. Mus, Axel Winkel, Carla Boetes, Jelle O. Barentsz, Jeroen Veltman


  • Open Access

    Computer-aided detection (CAD) for breast MRI: evaluation of efficacy at 3.0 T

    by Carla Meeuwis, Stephanie M. van de Ven, Gerard Stapper, Arancha M. Fernandez Gallardo, Maurice A. A. J. van Den Bosch, Willem P. Th. M. Mali, Wouter B. Veldhuis

    Objective The purpose of the study was to evaluate the accuracy of 3.0-T breast MRI interpretation using manual and fully automated kinetic analyses. Material and methods Manual MRI interpretation was done on an Advantage Workstation. Retrospectively, all examinations were processed with a computer-aided detection (CAD) system. CAD data sets were interpreted by two experienced breast radiologists and two residents. For each lesion automated analysis of enhancement kinetics was evaluated at 50% and 100% thresholds. Forty-nine malignant and 22 benign lesions were evaluated. Results Using threshold enhancement alone, the sensitivity and specificity of CAD were 97.9% and 86.4%, respectively, for the 50% threshold, and 97.9% and 90%, respectively, for the 100% threshold. Manual interpretation by two breast radiologists showed a sensitivity of 84.6% and a specificity of 68.8%. For the same two radiologists the mean sensitivity and specificity for CAD-based interpretation was 90.4% (not significant) and 81.3% (significant at p < 0.05), respectively. With one-way ANOVA no significant differences were found between the two breast radiologists and the two residents together, or between any two readers separately. Conclusion CAD-based analysis improved the specificity compared with manual analysis of enhancement. Automated analysis at 50% and 100% thresholds showed a high sensitivity and specificity for readers with varying levels of experience.