Mark Bachman

In this work, we demonstrate the use of a thin, self adherent, and clinically durable patch device that can collect fluid from a wound site for analysis. This device is manufactured from laminated silicone layers using a novel all-silicone double-molding process. In vitro studies for flow and delivery were followed by a clinical demonstration for exudate collection efficiency from a clinically presented partial thickness burn. The demonstrated utility of this device lends itself for use as a research implement used to clinically sample wound exudate for analysis. This device can serve as a platform for future integration of wearable technology into wound monitoring and care. The demonstrated fabrication method can be used for devices requiring thin membrane construction.

Large area magnetic micropallets with ferromagnetic cores were fabricated on translucent gold thin films enabling consistent laser release of individual cell colonies via vapor bubble formation beneath the pallets.

The direct hearing device (DHD) is a new auditory prosthesis that combines conventional hearing aid and middle ear implant technologies into a single device. The DHD is located deep in the ear canal and recreates sounds with mechanical movements of the tympanic membrane. A critical component of the DHD is the microactuator, which must be capable of moving the tympanic membrane at frequencies and magnitudes appropriate for normal hearing, with little distortion. The DHD actuator reported here utilized a voice coil actuator design and was 3.7 mm in diameter. The device has a smoothly varying frequency response and produces a precisely controllable force. The total harmonic distortion between 425 Hz and 10 kHz is below 0.5 % and acoustic noise generation is minimal. The device was tested as a tympanic membrane driver on cadaveric temporal bones where the device was coupled to the umbo of the tympanic membrane. The DHD successfully recreated ossicular chain movements across the frequencies of human hearing while demonstrating controllable magnitude. Moreover, the micro-actuator was validated in a short-term human clinical performance study where sound matching and complex audio waveforms were evaluated by a healthy subject.

It is thought that therapy should be functional, be highly repetitive, and promote afferent input to best stimulate hand motor recovery after stroke, yet patients struggle to access such therapy. We developed the MusicGlove, an instrumented glove that requires the user to practice gripping-like movements and thumb-finger opposition to play a highly engaging, music-based, video game. The purpose of this study was to 1) compare the effect of training with MusicGlove to conventional hand therapy 2) determine if MusicGlove training was more effective than a matched form of isometric hand movement training; and 3) determine if MusicGlove game scores predict clinical outcomes.

We describe a technology based on lamination that allows for the production of highly integrated 3D devices suitable for performing a wide variety of microfluidic assays. This approach uses a suite of microfluidic coupons (“microfloupons”) that are intended to be stacked as needed to produce an assay of interest. Microfloupons may be manufactured in paper, plastic, gels, or other materials, in advance, by different manufacturers, then assembled by the assay designer as needed. To demonstrate this approach, we designed, assembled, and characterized a microfloupon device that performs sodium-dodecyl-sulfate polyacrylamide gel electrophoresis on a small sample of protein. This device allowed for the manipulation and transport of small amounts of protein sample, tight injection into a thin polyacrylamide gel, electrophoretic separation of the proteins into bands, and subsequent removal of the gel from the device for imaging and further analysis. The microfloupons are rugged enough to handle and can be easily aligned and laminated, allowing for a variety of different assays to be designed and configured by selecting appropriate microfloupons. This approach provides a convenient way to perform assays that have multiple steps, relieving the need to design highly sophisticated devices that incorporate all functions in a single unit, while still achieving the benefits of small sample size, automation, and high speed operation.

We report a novel method for addressing a set of microelectromechanical system (MEMS) actuators using an oscillating signal to drive an actuator into resonance and then into a latched state. Based on the unique frequency response characteristics of individual actuators, multiplexed addressing of multiple devices in an array can be accomplished by selecting and combining appropriate driving signals on a single control line. This simplified control architecture of MEMS actuators eases implementation of multiple devices and enables large-scale integration of programmable microactuator systems, such as MEMS switch arrays.

We present novel hybrid microfabrication methods for microelectrode arrays that combine microwire assembly, microelectromechanical systems (MEMS) manufacturing techniques and precision tool-based micromachining. This combination enables hybrid microfabrication to produce complex geometries and structures, increase material selection, and improve integration. A 32-channel shank microelectrode array was fabricated to highlight the hybrid microfabrication techniques. The electrode shank was 130 μm at its narrowest, had a 127 μm thickness and had iridium oxide electrode sites that were 25 μm in diameter with 150 μm spacing. Techniques used to fabricate this electrode include microassembly of insulated gold wires into a micromold, micromolding the microelectrode shank, post molding machining, sacrificial release of the microelectrode and electrodeposition of iridium oxide onto the microelectrode sites. Electrode site position accuracy was shown to have a standard deviation of less than 4 μm. Acute in vivo recordings with the 32-channel shank microelectrode array demonstrated comparable performance to that obtained with commercial microelectrode arrays. This new approach to microelectrode array fabrication will enable new microelectrodes, such as multi-sided arrays, drug eluding electrodes and biodegradable shanks.

Microfluidic channels were studied, in which the surface is modified from a solid/liquid interface into solid/liquid and air/liquid alternating interface, creating the equivalent of a superhydrophobic surface on the interior of the channel. The composite microchannel can be easily fabricated using embossing or cast molding of PDMS. The channels are stable under typical microfluidic conditions. For the most part, fluid flow behavior is not significantly changed; however, interesting mass transport effects can be observed in such channels under appropriate conditions. An application example of a microvalve based on the mass transport effect is demonstrated, showing advantages of simple design, fabrication, no moving part and zero dead volume

Microfluidic droplet systems have shown great promise in high throughput chemical assays to minimize chemical consumption and increase process efficiency. We report a droplet system that forms nanovolume drops under static conditions. The programmability of drop sizes is determined by geometric configurations and surface tension, and not particularly sensitive to flow rates. The geometry of the device predetermines locations of drops, and thus it is easy to identify the locations of drops and the volumes of the drops within them. Further integration can be made to generate screening assays and utilized in various applications such as crystallization screening and solubility studies. This technology makes hand-operated systems a possibility, since precision control of flow rates is not necessary

Microfluidic channels were studied, in which the surface is modified from a solid/liquid interface into solid/liquid and air/liquid alternating interface, creating the equivalent of a superhydrophobic surface on the interior of the channel. The composite microchannel can be easily fabricated using embossing or cast molding of PDMS. The channels are stable under typical microfluidic conditions. For the most part, fluid flow behavior is not significantly changed; however, interesting mass transport effects can be observed in such channels under appropriate conditions. An application example of a microvalve based on the mass transport effect is demonstrated, showing advantages of simple design, fabrication, no moving part and zero dead volume