Daniel Schultz
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Daniel Schultz has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
Eshel Ben Jacob
Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093-0374; and
1 shared publication- José Nelson Onuchic
Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093-0374
1 shared publication Peter G. Wolynes
Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093-0374; and
1 shared publication
Latest Publications
- 6 November 2007
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 104 (45) , 17582-17587
Molecular level stochastic model for competence cycles in Bacillus subtilis
The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis . Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed point (vegetation) and an excitable unstable one (competence) is sufficient. Stochasticity therefore plays a crucial role in this excitation. Noise can be generated by discrete events such as RNA and protein synthesis and their degradation. We consider an alternative noise source connected with the protein binding/unbinding to the DNA. A theoretical model that includes this “nonadiabatic” mechanism appears to produce a better agreement with experiments than models where only the adiabatic limit is considered, suggesting that this nonconventional stochasticity source may be important for biological functions.
- 6 November 2007
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 104 (45) , 17582-17587
Molecular level stochastic model for competence cycles in Bacillus subtilis
The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis . Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed point (vegetation) and an excitable unstable one (competence) is sufficient. Stochasticity therefore plays a crucial role in this excitation. Noise can be generated by discrete events such as RNA and protein synthesis and their degradation. We consider an alternative noise source connected with the protein binding/unbinding to the DNA. A theoretical model that includes this “nonadiabatic” mechanism appears to produce a better agreement with experiments than models where only the adiabatic limit is considered, suggesting that this nonconventional stochasticity source may be important for biological functions.