Jason P. Weick
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Jason P. Weick has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
Su-Chun Zhang
Waisman Center
1 shared publicationYan Liu
Waisman Center
1 shared publication
Latest Publications
- Open Access
- 21 November 2011
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 108 (50) , 20189-20194
Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
Whether hESC-derived neurons can fully integrate with and functionally regulate an existing neural network remains unknown. Here, we demonstrate that hESC-derived neurons receive unitary postsynaptic currents both in vitro and in vivo and adopt the rhythmic firing behavior of mouse cortical networks via synaptic integration. Optical stimulation of hESC-derived neurons expressing Channelrhodopsin-2 elicited both inhibitory and excitatory postsynaptic currents and triggered network bursting in mouse neurons. Furthermore, light stimulation of hESC-derived neurons transplanted to the hippocampus of adult mice triggered postsynaptic currents in host pyramidal neurons in acute slice preparations. Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo.
- 21 November 2011
- Published by National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 108 (50) , 20189-20194
Open AccessHuman embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
Whether hESC-derived neurons can fully integrate with and functionally regulate an existing neural network remains unknown. Here, we demonstrate that hESC-derived neurons receive unitary postsynaptic currents both in vitro and in vivo and adopt the rhythmic firing behavior of mouse cortical networks via synaptic integration. Optical stimulation of hESC-derived neurons expressing Channelrhodopsin-2 elicited both inhibitory and excitatory postsynaptic currents and triggered network bursting in mouse neurons. Furthermore, light stimulation of hESC-derived neurons transplanted to the hippocampus of adult mice triggered postsynaptic currents in host pyramidal neurons in acute slice preparations. Thus, hESC-derived neurons can participate in and modulate neural network activity through functional synaptic integration, suggesting they are capable of contributing to neural network information processing both in vitro and in vivo.