Lin Bian

Background:In clinical practice, hearing thresholds are measured at only five to six frequencies at octave intervals. Thus, the audiometric configuration cannot closely reflect the actual status of the auditory structures. In addition, differential diagnosis requires quantitative comparison of behavioral thresholds with physiological measures, such as otoacoustic emissions (OAEs) that are usually measured in higher resolution.Purpose:The purpose of this research was to develop a method to improve the frequency resolution of the audiogram.Research Design:A repeated-measure design was used in the study to evaluate the reliability of the threshold measurements.Study Sample:A total of 16 participants with clinically normal hearing and mild hearing loss were recruited from a population of university students.Intervention:No intervention was involved in the study.Data Collection and Analysis:Custom developed system and software were used for threshold acquisition with quality control (QC). With real-ear calibration and monitoring of test signals, the system provided accurate and individualized measure of hearing thresholds that were determined by an analysis based on signal detection theory (SDT). The reliability of the threshold measure was assessed by correlation and differences between the repeated measures.Results:The audiometric configurations were diverse and unique to each individual ear. The accuracy, within-subject reliability, and between-test repeatability are relatively high.Conclusions:With QC, the high-resolution audiograms can be reliably and accurately measured. Hearing thresholds measured as ear canal sound pressures with higher frequency resolution can provide more customized hearing-aid fitting. The test system may be integrated with other physiological measures, such as OAEs, into a comprehensive evaluative tool.

Distortion product otoacoustic emissions (DPOAEs) were measured using sinusoidal amplitude modulation (AM) tones. When one of the primary stimuli (f(1) or f(2), f(1) < f(2)) was amplitude modulated, a series of changes in the cubic difference tone (CDT) were observed. In the frequency domain, multiple sidebands were present around the CDT and their sizes grew with the modulation depth of the AM stimulus. In the time domain, the CDT showed different modulation patterns between two major signal conditions: the AM tone was used as the f(1) or the f(2). The CDT amplitude followed the AM tone when the f(1) was amplitude modulated. However, when the AM tone acted as the f(2), the CDT showed a more complex modulation pattern with a notch present at the AM tone peak. The relatively linear dependence of CDT on f(1) and the nonlinear relation with f(2) can be explained with a variable gain-control model representing hair cell functions at the DPOAE generation site. It is likely that processing of AM signals at a particular cochlear location depends on whether the hair cells are tuned to the frequency of the carrier. Nonlinear modulation is related to on-frequency carriers and off-frequency carriers are processed relatively linearly.

Odd- and even-order distortion products (DPs), evoked by two primary tones ( f 1 , f 2 , f 1 < f 2 ) , represent different aspects of cochlear nonlinearity. The cubic and quadratic difference tones (CDT 2 f 1 − f 2 and QDT f 2 − f 1 ) are prominent representatives of the odd and even DPs. Distortion product otoacoustic emissions (DPOAEs) were measured within a primary level ( L 1 , L 2 ) space over a wide range of f 2 ∕ f 1 ratios to compare the optimal signal conditions for these DPs. For CDT, the primary level difference decreased as L 1 increased with a rate proportional to the f 2 ∕ f 1 ratio. Moreover, the optimal ratio increased with L 1 . A set of two formulas is proposed to describe the optimal signal conditions. However, for a given level of a primary, increasing the other tone level could maximize the QDT amplitude. The frequency ratio at the maximal QDT was about 1.3 and quite constant across different primary levels. A notch was found in the QDT amplitude at the f 2 ∕ f 1 ratio of about 1.22–1.25. These opposite behaviors suggest that the optimal recording conditions are different for CDT and QDT due to the different aspects in the cochlear nonlinearity. Optimizing the DPOAE recordings could improve the reliability in clinical or research practices.

It was previously reported that low-frequency biasing of cochlear structures can suppress and modulate the amplitudes of spontaneous otoacoustic emissions (SOAEs) in humans [Bian, L. and Watts, K. L. (2008). “Effects of low-frequency biasing on spontaneous otoacoustic emissions: Amplitude modulation,” J. Acoust. Soc. Am.123, 887–898]. In addition to amplitude modulation, the bias tone produced an upward shift of the SOAE frequency and a frequency modulation. These frequency effects usually occurred prior to significant modifications of SOAE amplitudes and were dependent on the relative strength of the bias tone and a particular SOAE. The overall SOAE frequency shifts were usually less than 2%. A quasistatic modulation pattern showed that biasing in either positive or negative pressure direction increased SOAE frequency. The instantaneous SOAE frequency revealed a “W-shaped” modulation pattern within one biasing cycle. The SOAE frequency was maximal at the biasing extremes and minimized at the zero crossings of the bias tone. The temporal modulation of SOAE frequency occurred with a short delay. These static and dynamic effects indicate that modifications of the mechanical properties of the cochlear transducer could underlie the frequency shift and modulation. These biasing effects are consistent with the suppression and modulation of SOAE amplitude due to shifting of the cochlear transducer operating point.

The dynamic effects of low-frequency biasing on spontaneous otoacoustic emissions (SOAEs) were studied in human subjects under various signal conditions. Results showed a combined suppression and modulation of the SOAE amplitudes at high bias tone levels. Ear-canal acoustic spectra demonstrated a reduction in SOAE amplitude and growths of sidebands while increasing the bias tone level. These effects varied depending on the relative strength of the bias tone to a particular SOAE. The SOAE magnitudes were suppressed when the cochlear partition was biased in both directions. This quasi-static modulation pattern showed a shape consistent with the first derivative of a sigmoid-shaped nonlinear function. In the time domain, the SOAE amplitudes were modulated with the instantaneous phase of the bias tone. For each biasing cycle, the SOAE envelope showed two peaks each corresponded to a zero crossing of the bias tone. The temporal modulation patterns varied systematically with the level and frequency of the bias tone. These dynamic behaviors of the SOAEs are consistent with the shifting of the operating point along the nonlinear transducer function of the cochlea. The results suggest that the nonlinearity in cochlear hair cell transduction may be involved in the generation of SOAEs.

Low-frequency modulation of distortion product otoacoustic emissions (DPOAEs) was measured from the human ears. In the frequency domain, increasing the bias tone level resulted in a suppression of the cubic difference tone (CDT) and an increase in the magnitudes of the modulation sidebands. Higher-frequency bias tones were more efficient in producing the suppression and modulation. Quasi-static modulation patterns were derived from measuring the CDT amplitude at the peaks and troughs of bias tones with various amplitudes. The asymmetric bell-shaped pattern resembled the absolute value of the third derivative of a nonlinear cochlear transducer function. Temporal modulation patterns were obtained from inverse FFT of the spectral contents around the DPOAE. The period modulation pattern, averaged over multiple bias tone cycles, showed two CDT peaks each correlated with the zero-crossings of the bias tone. The typical period modulation pattern varied and the two CDT peaks emerged with the reduction in bias tone level. The present study replicated the previous experimental results in gerbils. This noninvasive technique is capable of revealing the static position and dynamic motion of the cochlear partition. Moreover, the results of the present study suggest that this technique could potentially be applied in the differential diagnosis of cochlear pathologies.

Biasing of the cochlear partition with a low-frequency tone can produce an amplitude modulation of distortion product otoacoustic emissions (DPOAEs) in gerbils. In the time domain, odd- versus even-order DPOAEs demonstrated different modulation patterns depending on the bias tone phase. In the frequency domain, multiple sidebands are presented on either side of each DPOAE component. These sidebands were located at harmonic multiples of the biasing frequency from the DPOAE component. For odd-order DPOAEs, sidebands at the even-multiples of the biasing frequency were enhanced, while for even-order DPOAEs, the sidebands at the odd-multiples were elevated. When a modulation in DPOAE magnitude was presented, the magnitudes of the sidebands were enhanced and even greater than the DPOAEs. The amplitudes of these sidebands varied with the levels of the bias tone and two primary tones. The results indicate that the maximal amplitude modulations of DPOAEs occur at a confined bias and primary level space. This can provide a guide for optimal selections of signal conditions for better recordings of low-frequency modulated DPOAEs in future research and applications. Spectral fine-structure and its unique relation to the DPOAE modulation pattern may be useful for direct acquisition of cochlear transducer nonlinearity from a simple spectral analysis.