Kajari Mondal
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Kajari Mondal has a total of 53 co-authors. Here are the top co-authors by number of shared publications:
- Michael Edward Zwick
Department of Human Genetics, Emory University School of Medicine, Atlanta, USA
3 shared publications - Subra Kugathasan
Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta , Atlanta, GA
3 shared publications - David J. Cutler
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
2 shared publications - David J. Cutler
Emory University
2 shared publications David Okou
2 shared publications- Jeffrey S. Hyams
Connecticut Children’s Medical Center
2 shared publications
Latest Publications
- 1 May 2013
- Published by Elsevier in Gastroenterology
- Vol. 144 (5)
Su1743 Exome Sequencing Identify Novel Variants in African-Americans With Severe Perianal and Colonic Crohn's Disease
- 1 May 2013
- Published by Elsevier in Gastroenterology
- Vol. 144 (5)
Su1743 Exome Sequencing Identify Novel Variants in African-Americans With Severe Perianal and Colonic Crohn's Disease
- Open Access
- 20 September 2010
- Published by Springer Nature in BMC Bioinformatics
- Vol. 11 (1) , 471
SeqAnt: A web service to rapidly identify and annotate DNA sequence variations
Background: The enormous throughput and low cost of second-generation sequencing platforms now allow research and clinical geneticists to routinely perform single experiments that identify tens of thousands to millions of variant sites. Existing methods to annotate variant sites using information from publicly available databases via web browsers are too slow to be useful for the large sequencing datasets being routinely generated by geneticists. Because sequence annotation of variant sites is required before functional characterization can proceed, the lack of a high-throughput pipeline to efficiently annotate variant sites can act as a significant bottleneck in genetics research. Results: SeqAnt (Seq uence An notator) is an open source web service and software package that rapidly annotates DNA sequence variants and identifies recessive or compound heterozygous loci in human, mouse, fly, and worm genome sequencing experiments. Variants are characterized with respect to their functional type, frequency, and evolutionary conservation. Annotated variants can be viewed on a web browser, downloaded in a tab-delimited text file, or directly uploaded in a BED format to the UCSC genome browser. To demonstrate the speed of SeqAnt, we annotated a series of publicly available datasets that ranged in size from 37 to 3,439,107 variant sites. The total time to completely annotate these data completely ranged from 0.17 seconds to 28 minutes 49.8 seconds. Conclusion: SeqAnt is an open source web service and software package that overcomes a critical bottleneck facing research and clinical geneticists using second-generation sequencing platforms. SeqAnt will prove especially useful for those investigators who lack dedicated bioinformatics personnel or infrastructure in their laboratories.
- 20 September 2010
- Published by Springer Nature in BMC Bioinformatics
- Vol. 11 (1) , 471
Open AccessSeqAnt: A web service to rapidly identify and annotate DNA sequence variations
Background: The enormous throughput and low cost of second-generation sequencing platforms now allow research and clinical geneticists to routinely perform single experiments that identify tens of thousands to millions of variant sites. Existing methods to annotate variant sites using information from publicly available databases via web browsers are too slow to be useful for the large sequencing datasets being routinely generated by geneticists. Because sequence annotation of variant sites is required before functional characterization can proceed, the lack of a high-throughput pipeline to efficiently annotate variant sites can act as a significant bottleneck in genetics research. Results: SeqAnt (Seq uence An notator) is an open source web service and software package that rapidly annotates DNA sequence variants and identifies recessive or compound heterozygous loci in human, mouse, fly, and worm genome sequencing experiments. Variants are characterized with respect to their functional type, frequency, and evolutionary conservation. Annotated variants can be viewed on a web browser, downloaded in a tab-delimited text file, or directly uploaded in a BED format to the UCSC genome browser. To demonstrate the speed of SeqAnt, we annotated a series of publicly available datasets that ranged in size from 37 to 3,439,107 variant sites. The total time to completely annotate these data completely ranged from 0.17 seconds to 28 minutes 49.8 seconds. Conclusion: SeqAnt is an open source web service and software package that overcomes a critical bottleneck facing research and clinical geneticists using second-generation sequencing platforms. SeqAnt will prove especially useful for those investigators who lack dedicated bioinformatics personnel or infrastructure in their laboratories.