Nawal Hammas

A granular cell tumor involving the breast parenchyma was first described by Abrikossoff in 1931. Localization of this lesion to the breast is very rare, accounting for between 5% and 15% of all granular cell tumor cases. We present this case because of the rarity of this tumor. It is frequently confused with breast carcinoma on clinical and radiological examination, and its diagnosis can therefore be challenging for clinicians, radiologists and pathologists.

Le dermatofibrosarcome de Darier et Ferrand (DFS) est une tumeur m?senchymateuse cutan?e de malignit? interm?diaire. C'est une tumeur rare mais non exceptionnelle, repr?sentant 0,1% des tumeurs cutan?es malignes. Les auteurs pr?sentent une ?tude r?trospective de 27 cas de DFS diagnostiqu?s sur une dur?e de 7 ans (2004 ? 2010) et la comparent aux donn?es de la litt?rature. Cette ?tude permet d'?tablir en plus des caract?ristiques anatomopathologiques et immunohistochimiques, une ?tude ?pid?miologique, clinique et ?volutive de ce sarcome. l'?ge moyen de nos patients est de 41 ans avec une pr?dominance masculine. Le tronc est la localisation pr?f?rentielle touch? dans 52% des cas. La taille tumorale a atteint 30cm et mesure en moyenne 6,1 cm. Le diagnostic ?tait ?voqu? ? l'examen histologique standard et confirm? par l'expression intense et diffuse du CD34. Le traitement ?tait chirurgical, associ? ? une radioth?rapie dans 2 cas. L'?volution ?tait marqu?e par la transformation en un sarcome pl?omorphe de haut grade dans un cas et par la survenue de r?cidives locales dans 2 cas. Nos r?sultats sont classiques et comparables aux autres s?ries de la litt?rature. L'examen histologique est indispensable pour le diagnostic. L'ex?r?se chirurgicale large est le traitement de r?f?rence. Le pronostic est conditionn? par une malignit? surtout locale et un fort potentiel de r?cidive. La transformation sarcomateuse franchement maligne m?tastasiante est exceptionnelle.

Introduction: Primary signet-ring cell carcinoma of the urinary bladder is a rare variant of mucus-producing adenocarcinoma constituting approximately 0.5% to 2.0% of all primary carcinomas of the bladder. This tumor initially presents as a high-grade, high-stage lesion and diffusely invades the bladder wall without forming intraluminal growth. The patients have no specific symptoms, which leads to delayed diagnosis and poor prognosis. Case presentation: We report the case of a 51-year-old Moroccan Berber man consulting for gross hematuria. Ultrasonography and a computed tomography scan found a bladder tumor diffusely invading the bladder wall. A histopathological examination of the tumor chips from a transurethral resection of the bladder revealed signet-ring cell adenocarcinoma. The gastrointestinal tract exploration did not reveal any other tumor localization. A radical cystectomy and adjuvant cisplatin and gemcitabine chemotherapy were therefore performed resulting in 18 months of survival without metastasis and a good quality of life within that time. Conclusion: The rarity and the successful management with carboplatin and gemcitabine as adjuvant chemotherapy of this entity, which is rarely reported in the literature, are two remarkable characteristics described in this case report.

Eccrine carcinoma is an extremely rare malignancy of the skin with few well documented cases reported in the literature. It is frequently found on the lower extremities, and it equally affects both sexes in the sixth and seventh decade.

Multinucleated giant cell-containing tumors and pseudotumors of bone represent a heterogeneous group of benign and malignant lesions. Differential diagnosis can be challenging, particularly in instances of limited sampling. The purpose of this study was to evaluate the contribution of the P63 in the positive and differential diagnosis of giant cell tumor of bone.

Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. It represents 0.7% of all lung tumors. We report the case of a three-year-old child who suffered from a chronic cough with recurrent respiratory infections. Chest X-ray and computed tomography revealed the presence of a left lower lobe lung mass. After pneumonectomy, histological examination combined with immunohistochemical study discovered an inflammatory myofibroblastic tumor.