Soon-Wuk Jeong

Inter-individual variations in drug responses are major concerns in cancer treatment in human and veterinary oncology. Consequently, preclinical models have been proposed to predict drug responses and determine optimal individualized therapy. We aimed to evaluate the clinical utility of in vitro drug sensitivity testing using a patient-derived cell culture model to select appropriate adjuvant therapies for dogs with solid tumors. We screened medical records of 126 dogs with suspected tumors, including 33 dogs with solid tumors (guided group, 16; empirical group, 17). Anticancer drugs used for adjuvant therapy were determined based on in vitro drug sensitivity testing (guided group) or histopathological examination (empirical group) results. Time to tumor progression (TTP) was compared between groups. The guided group had significantly longer TTP than the empirical group (949 vs. 109 days). Median TTPs were significantly longer in the guided group than in the empirical group for dogs with incomplete surgical margin (949 vs. 109 days), dogs with mitotic count < 20 per 10 high power fields (949 vs. 105 days), dogs with no evidence of metastatic disease at initial diagnosis (455 vs. 196 days), and dogs receiving tyrosine kinase inhibitors (949 vs. 109 days). Our study suggests that in vitro drug sensitivity testing may be a useful tool for optimizing adjuvant therapy in dogs with solid tumors.

The purpose of this study was to measure how weight is distributed in the pads of each of the 4 limbs of dogs and evaluate the intra-investigator reproducibility and inter-investigator reliability of the measurement method. Eight dogs were examined 3 times a day by 3 investigators at 1 week intervals for 3 weeks to determine the weight distribution to each of the pads. The force-sensitive resistor was used for measurement and specific software (PetLAB2) was used to calculate the weight applied to each pad. The intra-investigator reproducibility showed moderate to good reliability (ICC range, 0.575-0.873) and the inter-investigator reliability was moderate (ICC range, 0.525-0.746). Based on this study, it can be observed whether the weight distributed to each pad approaches the normal value after treatment in patients with orthopaedic and neurologic diseases. It is expected that this experimental method will be one of the objective indicators to evaluate the degree of recovery in patients with orthopaedic and neurologic diseases.

Jeong SW. J Vet Sci. 2022 Jul;23(4):e69. https://doi.org/10.4142/jvs.22199

Seung-Ho Ryu, Chull-Gyu Park, Ho-Seong Kim, Yeong-Hun Kim, Byung-Sun Kim, Soon-Wuk Jeong. J Vet Clin 2022;39:28-31. https://doi.org/10.17555/jvc.2022.39.1.28

Chun-Ki Choi, Hye-Jin Jung, Soon-Wuk Jeong. J Vet Clin 2022;39:32-7. https://doi.org/10.17555/jvc.2022.39.1.32

Ahn SY, et al. J Vet Sci. 2022 Feb;23:e38. https://doi.org/10.4142/jvs.21249

Yoo YH, et al. J Vet Sci. 2019 Oct;21:e69. https://doi.org/10.4142/jvs.2020.21.e69

Choi JW, et al. Immune Netw. 2016 Apr;16(2):116-125. https://doi.org/10.4110/in.2016.16.2.116