Vladimir A. Popov

Background/Objectives: Patients with rheumatoid arthritis (RA) are prone to develop infections. Methods: Accordingly, 195 untreated early (e)RA patients and 398 healthy controls were selected from women in Tatarstan’s cohort to study infectious history in the anamnesis (four criteria) and in the previous year (16 criteria). Information about annual infections was collected face-to-face from year to year by a qualified rheumatologist/general practitioner and included the active use of information from medical records. Results: In the anamnesis, tuberculosis, and pneumonia, and in the previous year, respiratory tract infections, skin infections, and herpes simplex virus reactivation incidence were reported to be increased in eRA patients, as well as the event number and duration of acute and chronic tonsillitis. Moreover, more bacterial-suspected upper respiratory infections and urinary tract infections were retrieved in sporadic eRA patients as compared to familial eRA patients. An elevated immunization against CCP prevented respiratory tract infection in those with HSV exacerbation. Finally, associations were retrieved between infection (event number/delay) and RA indices: (i) chronic tonsillitis exacerbations with disease activity and health assessment (HAQ) in familial eRA; (ii) bacterial-suspected upper respiratory infections with the number of swollen and tender joints in sporadic eRA; and (iii) HSV exacerbation with inflammation in eRA patients with negative/low response against CCP. Here, we demonstrate the complex nature of the interplay of RA with specific infections. Conclusions: For the first time, differences in the patterns of annual trivial infections and their links with RA indices were found in cohorts of familial and sporadic cases of the disease. Additionally, for the first time, we identified a remarkable relationship between early RA and exacerbations of chronic tonsillitis, as well as tuberculosis in the patient’s history. Altogether, this study supports the existence of a complex interplay between infections and RA at onset driven by familial status and the presence of anti-CCP Ab at elevated levels.

We consider galaxy halos formed by dark matter bosons with mass in the range of about a few tens or hundreds eV. A major part of the particles is in a noncondensed state and described under the Thomas-Fermi approach. Derived equations are solved numerically to find the halo density profile. The noncondensed state is supported in the entire halo except compact gravitationally bounded Bose-Einstein condensates. Although the size of these compact objects, also known as Bose stars, depends on interactions between the particles, its upper limit is only about 100 astronomical units. The Bose stars collect the condensed bosons providing a density cusp avoidance in the halo as well as a natural mechanism to prevent overproduction of small halos. Clusters of the Bose stars can also contribute to the halo density profile. The model is analyzed by confronting its predictions with observations of galaxy rotation curves. We employ 22 low surface brightness galaxies and obtain that the model is consistent with the observational data when the particle mass is in the range above about 50 eV and the best fit corresponds to the mass m = 86 eV. This mass is appropriate for relic dark matter bosons, which decouple just after QCD phase transition.

In the framework of the Einstein-aether theory we consider a cosmological model, which describes the evolution of the unit dynamic vector field with activated rotational degree of freedom. We discuss exact solutions of the Einstein-aether theory, for which the space-time is of the Gödel-type, the velocity four-vector of the aether motion is characterized by a non-vanishing vorticity, thus the rotational vectorial modes can be associated with the source of the universe rotation. The main goal of our paper is to study the motion of test relativistic particles with a vectorial internal degree of freedom (spin or polarization), which is coupled to the unit dynamic vector field. The particles are considered as the test ones in the given space-time background of the Gödel-type; the spin (polarization) coupling to the unit dynamic vector field is modeled using exact solutions of three types. The first exact solution describes the aether with arbitrary Jacobson's coupling constants; the second one relates to the case, when the Jacobson's constant responsible for the vorticity is vanishing; the third exact solution is obtained using three constraints for the coupling constants. The analysis of the exact expressions, which are obtained for the particle momentum and for the spin (polarization) four-vector components, shows that the interaction of the spin (polarization) with the unit vector field induces a rotation, which is additional to the geodesic precession of the spin (polarization) associated with the universe rotation as a whole.

We consider a covariant phenomenological model, which describes an interaction between a pseudoscalar (axion) field and massive spinning particles. The model extends the Bagrmann-Michel-Telegdy approach in application to the axion electrodynamics. We present some exact solutions and discuss them in the context of experimental tests of the model and axion detection.

We establish a new covariant phenomenological model, which describes an influence of pseudoscalar (axion) field on spins of test massive particles. The model includes general relativistic equations of particle motion and spin evolution in background pseudoscalar (axion), electromagnetic and gravitational fields. It describes both the direct spin-axion coupling of the gradient type and indirect spin-axion interaction mediated by electromagnetic fields. Special attention is paid to the direct spin-axion coupling caused by the gradient of the pseudoscalar (axion) field. We show that it describes a spin precession, when the pseudoscalar (axion) field is inhomogeneous and/or nonstationary. Applications of the model, which correspond to the three types of four-vectors attributed to the gradient of the pseudoscalar (axion) field (timelike, spacelike, and null), are considered in detail. These are the spin precessions induced by relic cosmological axions, axions distributed around spherically symmetric static objects, and axions in a gravitational wave field, respectively. We discuss features of the obtained exact solutions and some general properties of the axionically induced spin rotation.

Chaplygin anisotropic matter governing the cosmological evolution in two identical universes with an intermediate static spherically symmetric region is considered. The static region contains a wormhole allowing one to pass between two horizons. The metric in the nonstatic region represents a kind of an anisotropic Kantowski–Sachs cosmological model starting from a horizon instead of the initial singularity. A classification of the cosmologies with a monotonic late stage is presented. It is shown that only one scenario can involve a de Sitter regime. The scales in the de Sitter phase allows one to describe the earliest accelerated expansion on the classical level.

Chaplygin anisotropic matter governing the cosmological evolution in two identical universes with an intermediate static spherically symmetric region is considered. The static region contains a wormhole allowing one to pass etween two horizons. The metric in the non-static region represents a kind of an anisotropic Kantowski-Sachs cosmological model starting from a horizon instead the initial singularity. A classification of the cosmologies with a monotonic late stage is presented. It is shown that only one scenario can involve a de Sitter regime. The scales in the de Sitter phase allows one to describe the earliest accelerated expansion on the classical level.