Hassan B. Kazemian

Membrane proteins are a major focus for new drug discovery. Transmembrane beta-barrel (TMB) proteins play key roles in the translocation machinery, pore formation, membrane anchoring and ion exchange. Given their key roles and the difficulty in membrane protein structure determination, the use of computational modeling is essential. This paper focuses on the topology prediction of TMB proteins. In the field of bioinformatics, many years of research has been spent on the topology prediction of transmembrane alpha-helices. The efforts to TMB proteins topology prediction have been overshadowed and the prediction accuracy could be improved with further research. Various methodologies have been developed in the past for the prediction of TMB protein topology, however, the use of cascading classifier has never been fully explored. This research presents a novel approach to TMB topology prediction with the use of a cascading classifier. The MATLAB computer simulation results show that the proposed methodology predicts TMB proteins topologies with high accuracy for randomly selected proteins. By using the cascading classifier approach, the best overall accuracy is 76.3% with a precision of 0.831 and recall or probability of detection of 0.799 for TMB topology prediction. The accuracy of 76.3% is achieved using a two-layers cascading classifier.

Neuro Linguistic Programming (NLP) is a collection of techniques for personality development. Meta programmes, which are habitual ways of inputting, sorting and filtering the information found in the world around us, are a vital factor in NLP. Differences in meta programmes result in significant differences in behaviour from one person to another. Personality types can be recognized through utilizing and analysing meta programmes. There are different methods to predict personality types based on meta programmes. The Myers–Briggs Type Indicator^® (MBTI) is currently considered as one of the most popular and reliable methods. In this study, a new machine learning method has been developed for personality type prediction based on the MBTI. The performance of the new methodology presented in this study has been compared to other existing methods and the results show better accuracy and reliability. The results of this study can assist NLP practitioners and psychologists in regards to identification of personality types and associated cognitive processes.