Taisiya V. Moskovkina
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Taisiya V. Moskovkina has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
A. I. Kalinovskii
Russian Academy of Sciences
3 shared publications- Irina G. Agafonova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia
2 shared publications - A. I. Kalinovskii
G. V. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok, Russia
1 shared publication Anatoly I. Kalinovskii
Russian Academy of Sciences
1 shared publicationE. A. Martyyas
G. V. Elyakov Pacific Ocean Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences, Vladivostok, Russia
1 shared publication- Ekaterina G. Lyakhova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia
1 shared publication
Latest Publications
- 7 August 2018
- Published by Springer Nature in Environmental Monitoring and Assessment
- Vol. 190 (9) , 502
Low-dose action of tryptanthrin and its derivatives against developing embryos of the sea urchin Strongylocentrotus intermedius
Nine tryptanthrin derivatives, including tryptanthrin itself, were synthesized using different methods, including oxidation of the corresponding isatins to obtain 1–4, the reaction of tryptanthrin 1 with hydrazine and its derivatives to obtain 5–7, and aldol condensation of 1 with acetone and methylethylketone to obtain 8 and 9. The action of 1–9 in doses corresponding to the IC50 against developing embryos of the sea urchin Strongylocentrotus intermedius and in the sperm test allowed us to estimate to potency of all the compounds and to determine which were cytotoxic. In addition, these studies showed that compounds 3, 4, 8, and 9 had a stimulatory effect at lower doses. In particular, the tryptanthrin derivatives stimulated the larval stages of development in surviving embryos at concentrations lower than the IC50.
- 7 August 2018
- Published by Springer Nature in Environmental Monitoring and Assessment
- Vol. 190 (9) , 502
Low-dose action of tryptanthrin and its derivatives against developing embryos of the sea urchin Strongylocentrotus intermedius
Nine tryptanthrin derivatives, including tryptanthrin itself, were synthesized using different methods, including oxidation of the corresponding isatins to obtain 1–4, the reaction of tryptanthrin 1 with hydrazine and its derivatives to obtain 5–7, and aldol condensation of 1 with acetone and methylethylketone to obtain 8 and 9. The action of 1–9 in doses corresponding to the IC50 against developing embryos of the sea urchin Strongylocentrotus intermedius and in the sperm test allowed us to estimate to potency of all the compounds and to determine which were cytotoxic. In addition, these studies showed that compounds 3, 4, 8, and 9 had a stimulatory effect at lower doses. In particular, the tryptanthrin derivatives stimulated the larval stages of development in surviving embryos at concentrations lower than the IC50.
- 1 March 2017
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 53 (3) , 418-422
Synthesis and antimicrobial activity of tryptanthrin adducts with ketones
Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.
- 1 March 2017
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 53 (3) , 418-422
Synthesis and antimicrobial activity of tryptanthrin adducts with ketones
Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.
- 1 August 2015
- Published by Springer Nature in Chemistry of Heterocyclic Compounds
- Vol. 51 (8) , 769-771
The structure of product from an unusual cyclization of 2,2'-methylenedicyclohexanone diphenylhydrazone
- 1 August 2015
- Published by Springer Nature in Chemistry of Heterocyclic Compounds
- Vol. 51 (8) , 769-771
The structure of product from an unusual cyclization of 2,2'-methylenedicyclohexanone diphenylhydrazone
- 23 April 2015
- Published by Springer Nature in Applied Magnetic Resonance
- Vol. 46 (7) , 781-791
Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging
- 23 April 2015
- Published by Springer Nature in Applied Magnetic Resonance
- Vol. 46 (7) , 781-791
Studies on Anti-Inflammatory Action of Tryptanthrin, Using a Model of DSS-Induced Colitis of Mice and Magnetic Resonance Imaging
- 1 December 2013
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 49 (12) , 1740-1743
Synthesis of substituted tryptanthrins via oxidation of isatin and its derivatives
Oxidation of isatin and its 5-substituted analogs with potassium permanganate in anhydrous acetonitrile gave indolo[2,1- b]quinazoline-6,12-dione (tryptanthrin) and its 2,8-dimethyl-, 2,8-dibromo-,...
- 1 December 2013
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 49 (12) , 1740-1743
Synthesis of substituted tryptanthrins via oxidation of isatin and its derivatives
Oxidation of isatin and its 5-substituted analogs with potassium permanganate in anhydrous acetonitrile gave indolo[2,1- b]quinazoline-6,12-dione (tryptanthrin) and its 2,8-dimethyl-, 2,8-dibromo-,...
- 22 June 2013
- Published by Springer Nature in Chemistry of Heterocyclic Compounds
- Vol. 49 (3) , 452-456
Synthesis and properties of 6,6-di(indol-3-yl)-indolo[2,1-b]quinazolin-12(6H)-one and its 2,8-dimethyl and 2,8-dibromo derivatives
- 22 June 2013
- Published by Springer Nature in Chemistry of Heterocyclic Compounds
- Vol. 49 (3) , 452-456
Synthesis and properties of 6,6-di(indol-3-yl)-indolo[2,1-b]quinazolin-12(6H)-one and its 2,8-dimethyl and 2,8-dibromo derivatives
- 1 January 2012
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 48 (1) , 123-126
Synthesis of tryptanthrin (couroupitine) derivatives by reaction of substituted isatins with phosphoryl chloride
Reaction of 5-methyl-, 5-bromo-, and 5-iodoisatins with phosphoryl chloride gave the corresponding 2,8-disubstituted indolo[2,1-b]quinazoline-6,12-diones in moderate yield. 5,7-Dichloroisatin failed to react with POCl3. Treatment of an equimolar mixture of isatin and 5-bromoisatin with POCl3 afforded indolo[2,1-b]-quinazoline-6,12-dione (tryptanthrin), 2,8-dibromoindolo[2,1-b]quinazoline-6,12-dione, and two isomeric monobromo-substituted tryptanthrin derivatives, the 2-bromo isomer prevailing.
- 1 January 2012
- Published by Pleiades Publishing Ltd in Russian Journal of Organic Chemistry
- Vol. 48 (1) , 123-126
Synthesis of tryptanthrin (couroupitine) derivatives by reaction of substituted isatins with phosphoryl chloride
Reaction of 5-methyl-, 5-bromo-, and 5-iodoisatins with phosphoryl chloride gave the corresponding 2,8-disubstituted indolo[2,1-b]quinazoline-6,12-diones in moderate yield. 5,7-Dichloroisatin failed to react with POCl3. Treatment of an equimolar mixture of isatin and 5-bromoisatin with POCl3 afforded indolo[2,1-b]-quinazoline-6,12-dione (tryptanthrin), 2,8-dibromoindolo[2,1-b]quinazoline-6,12-dione, and two isomeric monobromo-substituted tryptanthrin derivatives, the 2-bromo isomer prevailing.