Zh. R. Idrissova
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Zh. R. Idrissova has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
A. S. Petrukhin
Russian State Medical University, Moscow, Russia
1 shared publicationE. P. Dekonenko
Institute of Poliomyelitis and Viral Encephalitis, Moscow, Russia
1 shared publicationI. N. Martinenko
Institute of Poliomyelitis and Viral Encephalitis, Moscow, Russia
1 shared publicationI. Y. Leontyeva
First Clinical Infections Hospital, Moscow, Russia
1 shared publicationM. N. Boldyreva
Institute of Immunology, Moscow, Russia
1 shared publicationN. A. Malishev
First Clinical Infections Hospital, Moscow, Russia
1 shared publication
Latest Publications
- 27 August 2003
- Published by Wiley in European Journal of Neurology
- Vol. 10 (5) , 537-546
Acute disseminated encephalomyelitis in children: clinical features and HLA‐DR linkage
This study includes 90 children (41 female and 49 male) in the age range of 2–16 years with acute disseminated encephalomyelitis (ADEM). Thirty‐three patients developed ADEM following rubella infection, 26 children following varicella infection, 20 suspected viral aetiology ADEM and 11 multiphasic disseminated encephalomyelitis (MDEM). All patients had neurological, routine laboratory and viral serology study with an enzyme‐linked immunosorbent assay. Brain and/or spinal cord magnetic resonance imaging (MRI) were performed in 14 children. A follow‐up study was in 1–5 years. Typing of DRB1 gene HLA class II was performed in 38 patients. We established that the varicella and rubella groups had preferential patterns. Rubella ADEM is characterized by acute explosive onset, seizures, coma and moderate pyramidal signs, whereas varicella infection is characterized by cerebella ataxia and mild pyramidal dysfunction. The suspected viral aetiology ADEM was characterized by polisymptomatic presentation. MDEM was characterized by older age of patients (11.6 ± 2.8 years), more severe and prolonged local neurological symptoms, including myelitis symptoms and marked extrapyramidal signs, with distinct demyelination in MRIs. As a whole, ADEM is associated with DRB1*01 and DRB1*017(03) in the Russian population. Thus, ADEM is a separate autoimmune condition with a specific mechanism due to the type of genetic immunoregulatory base and specificity of viral trigger.
- 27 August 2003
- Published by Wiley in European Journal of Neurology
- Vol. 10 (5) , 537-546
Acute disseminated encephalomyelitis in children: clinical features and HLA‐DR linkage
This study includes 90 children (41 female and 49 male) in the age range of 2–16 years with acute disseminated encephalomyelitis (ADEM). Thirty‐three patients developed ADEM following rubella infection, 26 children following varicella infection, 20 suspected viral aetiology ADEM and 11 multiphasic disseminated encephalomyelitis (MDEM). All patients had neurological, routine laboratory and viral serology study with an enzyme‐linked immunosorbent assay. Brain and/or spinal cord magnetic resonance imaging (MRI) were performed in 14 children. A follow‐up study was in 1–5 years. Typing of DRB1 gene HLA class II was performed in 38 patients. We established that the varicella and rubella groups had preferential patterns. Rubella ADEM is characterized by acute explosive onset, seizures, coma and moderate pyramidal signs, whereas varicella infection is characterized by cerebella ataxia and mild pyramidal dysfunction. The suspected viral aetiology ADEM was characterized by polisymptomatic presentation. MDEM was characterized by older age of patients (11.6 ± 2.8 years), more severe and prolonged local neurological symptoms, including myelitis symptoms and marked extrapyramidal signs, with distinct demyelination in MRIs. As a whole, ADEM is associated with DRB1*01 and DRB1*017(03) in the Russian population. Thus, ADEM is a separate autoimmune condition with a specific mechanism due to the type of genetic immunoregulatory base and specificity of viral trigger.