Dong Sun

Tungsten disulfide (WS₂) nanosheets were obtained by exfoliating WS₂ bulk crystals in N-methylpyrrolidone by ultrasonication. Gold nanoparticles (GNPs) were synthesized by in-situ ultrasonication of sodium citrate and HAuCl₄ while fabricating the WS₂ nanosheets. In this way, the GNPs were self-assembled on WS₂ nanosheets to form a GNPs/WS₂ nanocomposite through interaction between sulfur and gold atoms. The photoelectrochemical response of WS₂ nanosheets is significantly enhanced after integration of the GNPs. The GNPs/WS₂ nanocomposite was coated onto a glassy carbon electrode (GCE) to construct a sensing interface which then was modified with an antibody against the carcinoembryonic antigen (CEA) to obtain a photoelectrochemical immunosensor for CEA. Under optimized conditions, the decline in relative photocurrent is linearly related to the logarithm of the CEA concentration in the range from 0.001 to 40 ng mL⁻¹. The detection limit is 0.5 pg mL⁻¹ (at S/N = 3). The assay is sensitive, selective, stable and reproducible. It was applied to the determination of CEA in clinical serum samples.

A mesoporous silica was synthesised and used to modify the surface of carbon paste electrode (CPE). The electrochemical behaviours of p-aminophenol were investigated. Compared to the unmodified CPE, the mesoporous silica-modified CPE obviously lowers the oxidation potential of p-aminophenol, and remarkably increases its oxidation peak current. The effects of pH value, amount of mesoporous silica, accumulation potential and time were examined. As a result, a sensitive, rapid and convenient electroanalytical method was developed for p-aminophenol. The linear range is from 0.025 mg L⁻¹ to 3 mg L⁻¹, and the limit of detection is 0.01 mg L⁻¹ after 2-min accumulation. Finally, the method was successfully used to determine p-aminophenol in water samples.